
Types of Corneal Grafts

Pentrating Keratoplasty (Full thickness graft)

Approx 8mm doner button sutered into place

DMEK/DSAEK
Descemet's membrane endothelial keratoplasty

Only the posterior surface is replaced, often a single cell layer

DALK Deep Anterior Lamellar Keratoplasty

The majority of the anterior cornea is replaced leaving the posterior surface intact
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What are the options?
As you might have noticed, there is still much to learn about this group of conditions. While keratoconus may sometimes be associated with other general health disorders, and there is some suggestion of a genetic link, this connection is not particularly strong. What does stand out, however, is that patients with keratoconus often experience or are prone to inflammatory events, such as allergies or immune-related conditions like systemic inflammatory diseases.
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One common observation is that keratoconic patients tend to rub their eyes frequently. While it remains unclear whether eye rubbing is a cause or a consequence of keratoconus, the best advice is to STOP rubbing the eyes. Eye rubbing can exacerbate the condition, so it’s crucial to manage any underlying ocular inflammation, such as hay fever, by using appropriate medications and/or ocular lubricants. Taking these steps can help protect the cornea and support overall eye health.
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Here’s an overview of the available options to support patients living with keratoconus or other forms of ectasia.
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Collagen cross-linking
Collagen cross-linking is an essential consideration for all patients diagnosed with keratoconus or other forms of corneal ectasia, particularly younger individuals. While this treatment does not cure the condition, it is highly effective in halting its progression and preventing further changes to the cornea, thereby stabilising vision and preserving eye health. ​ To monitor the condition effectively, corneal topography is essential. This advanced imaging technique, available at Thompson & Hardwick Optometrists, allows for detailed mapping of the cornea, ensuring accurate tracking of any changes. If corneal topography is not available, a referral to the hospital eye service is necessary to ensure proper management and care. This innovative procedure works by strengthening the weakened corneal structure characteristic of keratoconus. By combining riboflavin (vitamin B2) eye drops and controlled UV light, collagen cross-linking reinforces the collagen fibers in the cornea. This minimally invasive treatment stabilizes the corneal shape, reducing the risk of further thinning or distortion, and helps maintain long-term visual stability. If you or someone you know is managing keratoconus, collagen cross-linking could be a key step in protecting and preserving vision for the future.

Contact Lenses
Some people believe that contact lenses can improve keratoconus by reshaping the eye, while others worry that they might make the condition worse. Fortunately, neither of these statements is true. A properly fitted contact lens should not alter the shape of the cornea, nor should it cause inflammation that could contribute to the progression of the condition. Contact lenses are specifically designed to provide better vision correction by addressing the irregular shape of the eye. The best lenses achieve this through the refractive power and shape manipulation of the liquid tear lens, a truly remarkable process that works like magic! Lenses can be worn in almost all cases and can really be a game changer. Check out the lens options available here at Thompson & Hardwick Optometrists, these lenses are kind of our thing!

Corneal graft
Corneal graft surgery has the potential to be truly sight-saving, but it does come with its own set of risks. Lifelong use of anti-inflammatory and immunosuppressant eye drops is often required, and there is always the possibility of infection or graft rejection. However, advancements in modern surgical techniques are continually improving outcomes. While the traditional full-thickness graft is becoming less common, partial-thickness grafts are now more prevalent in keratoconic patients. These procedures typically offer better refractive outcomes, faster recovery times, and a reduced risk of infection and rejection. That said, graft surgery is not a cure for keratoconus. Many patients will still require contact lenses after surgery to achieve optimal vision. Careful consideration should always be given before proceeding with graft surgery, as it is typically reserved for cases where other therapies are not viable. Nevertheless, when indicated, graft surgery can be highly successful and, for some, truly life-changing.
What is Ectasia of the Cornea?
Ectasia, also known as ectasis, is a term derived from the Greek word meaning "dilation" or "distention" of a tubular structure. In the context of the cornea, which is composed of a highly organised arrangement of collagen tubular fibers, ectasia refers to a group of conditions where this structural integrity is compromised. Such disruptions can lead to significant visual impairments. As the cornea accounts for approximately 90% of the eye's focusing power, any alteration to its structure can have a profound impact on the overall focusing ability of the visual system.

Typical age of onset is between 10 and 25, and can usually to the age of 30. Risks include a family history, eye rubbing, and atopic (allergic) conditions like asthma, eczema, or hay fever.
Keratoconus

Typically present from birth (congenital) but can also develop later in life. Risk factors include genetic predisposition, connective tissue disorders such as Ehlers-Danlos syndrome or Marfan syndrome, and trauma to the eye.
Keratoglobus

Often starts asymptomatically in adulthood, usually between the ages of 20 and 40, and primarily affects men more than women. Risks are not well-known but may include a genetic predisposition and chronic inflammation.
Terriens

Pellucid Marginal Degeneration (PMD)
Usually presents in mid life between the ages of 20 and 40 but crucially can continue progress throughout life. Risks may include genetic predisposition, chronic eye rubbing and certain systemic conditions like connective tissue disorders.

Achieving Growth
ECTASIA
A group of conditions that alter the shape of the cornea, often referred to as the "window of the eye," with keratoconus being by far the most common among them.